This means there's potential for a cure down the road.
. The latter—an extreme, persistent nausea and vomiting—is rare, affecting only about 2 percent of pregnancies. And it’s severe: It can lead to weight loss, land you in the hospital with dehydration and even affect baby’s development. Anyone who has experienced hyperemesis gravidarum knows it’s the real deal, and studies are working to pinpoint the cause in order to emphasize it’s a physical, not a psychological, condition. Now one study is finding it may be linked to a gene mutation.
The researchers hope their findings will help not only diagnose HG in a more timely manner, perhaps through genetic testing, but also help build more effective treatments that target the underlying cause. “For generations, it’s been thought that HG was either psychological in nature or caused by the hCG pregnancy hormone, so this breakthrough leads us in a new direction,” Marlena Fejzo, PhD, a faculty researcher at the Keck School of Medicine and the paper’s lead author, said in a.
For the new study, researchers were able to pinpoint two variations of the GDF15 gene that strongly correlated to HG. The new study also looked at a more diverse participant pool and found race didn’t play a strong role in the results. Next, the researchers hope to find ways the correlation between GDF15 and HG may help improve diagnosis, as well as treatment options, including possibly developing medications that “block the GDF15 signaling pathway.
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