A common medical dye appeared to counteract the effects of the death cap mushroom in new research.
Their expansive search led them to one potential key protein called STT3B. Then they looked for existing drugs that might interfere with the interaction between STT3B and alpha-amanitin, finding indocyanine green . Finally, to test their hypothesiss hoped for, ICG substantially inhibited the mushroom’s toxicity. Less than 25% of mice exposed today mark, for instance, compared to 50% of those also given ICG.
“This molecule holds immense potential for treating cases of human mushroom poisoning and could mark the first-ever specific antidote with a targeted protein,” senior study author Qiaoping Wang, a researcher at China’s Sun Yat-sen University,The findings will have to be validated with more studies. But since ICG is already widely used in humans as a fluorescent medical dye, that should make it easier to safely test it out as a potential death cap cure.
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