Super ager brains contain 'super neurons' northwesternu sfnjournals
"The remarkable observation that super agers showed larger neurons than their younger peers may imply that large cells were present from birth and are maintained structurally throughout their lives," said lead author Tamar Gefen, an assistant professor of psychiatry andat Northwestern University Feinberg School of Medicine."We conclude that larger neurons are a biological signature of the SuperAging trajectory.
"To understand how and why people may be resistant to developing Alzheimer's disease, it is important to closely investigate the postmortem brains of super agers," Gefen said."What makes super agers' brains unique? How can we harness their biologic traits to help elderly stave off Alzheimer's disease?"
In the study, scientists show that super agers harbor large, healthier neurons in layer II of the entorhinal cortex compared to their same-aged peers, individuals with early stages of Alzheimer's disease and even individuals 20 to 30 years younger. They also showed that these large layer II neurons were spared from the formation of tau tangles.
For reasons that remain unknown, cell populations in the entorhinal cortex are selectively vulnerable to tau tangle formation during normal aging and in early stages of Alzheimer's.appears to be a characteristic marker of the disease," Gefen said.
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