Researchers at Tufts University School of Dental Medicine believe that targeting the bacteria that cause periodontal disease could slow the progression of Alzheimer's. The bacteria Fusobacterium nucleatum (F. nucleatum) often flourishes in periodontal disease. It has an influence on the jawbone a
often flourishes in periodontal disease. It has an influence on the jawbone and gums, and if left untreated, can lead to unstable teeth and tooth loss.has been connected in recent years to a variety of disorders, including premature birth and colorectal cancer.F. nucleatumFrontiers in Aging Neuroscience.
Possible links between periodontal disease and Alzheimer’s have been posited by scientists in the past. While the new research does not show that-related periodontal disease leads directly to Alzheimer’s disease, the new study suggests that periodontal disease caused byand left untreated or poorly treated could exacerbate symptoms of Alzheimer’s disease, Chen believes.
In particular, his lab is focused on two noncoding RNAs. One—microRNA—regulates the production of proteins in cells. Another—lncRNA—performs other functions to regulate gene expression and could ultimately be used to treat atherosclerosis as well as periodontal disease, diabetes, cancer, and diabetic bone disease.
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