An important step toward next-generation probiotics
Participants
Participating volunteers were recruited through advertising in social media and through posters in public areas . Participants who met all inclusion criteria , lacked all exclusion criteria , had normal blood biochemistry, blood pressure and heart rate, were invited to participate.The primary outcome was tolerability and was tested using discontinuation due to investigational product during 8 weeks of treatment.
At the randomization visit, faecal samples were collected and GSRS was completed in order to collect information of any gastrointestinal symptoms the preceding week. All participants received a diary for recording daily doses taken and to make notes about any potential adverse events. During study visits three to five, faeces and blood samples as well as data from the GSRS questionnaire form were collected.
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