The brain's support cells may play a key role in OCD nature
"We really have to look at the proteins because they are very complex and diverse," said co-author Joselyn Soto, a neuroscience Ph.D. student at UCLA's medical school."Depending on which cell expresses which proteins, we can predict the functions of that cell."
The researchers tested their findings by inserting the SAPAP3 protein back into neurons and astrocytes of mice that had been genetically modified to lack the gene that makes the protein. They found that the two types of cells interacted in different ways when they measured the protein's effects on compulsion and anxiety, two of the typical hallmarks of OCD.
Soto said future research would delve deeper into how the interactions between these cells affect behavior.
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