A study published in BMCMusculoSkeletDisord aims to identify whether supplementing women with calcium during load carriage in military field exercises is protective of bone and calcium homeostasis.
; will be eumenorrhoeic or using the combined oral contraceptive pill, an intrauterine system, or intrauterine device; be weight stable, defined as no change in self-reported body mass ≥ 5% over the previous 3 months; have a BMI between 18 and 30 kg·m, and; not be pregnant or lactating.
Regular and Reserve military servicewomen, and female civilians, will be invited to volunteer. Individuals interested in particpating will contact the investigators, upon which they will recieve a Participant Information Sheet and be invited to a phone conversation. The study aims, requirements, right to withdraw, and risks will be outlined. This study has received favourable ethical opinion from the Ministry of Defence Research Ethics Committee .
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Graves’ disease after exposure to the SARS-CoV-2 vaccine: a case report and review of the literature - BMC Endocrine DisordersBackground Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) is characterized by immune system dysregulation after exposure to adjuvants, such as aluminum. Although cases of autoimmune thyroid diseases caused by ASIA have been reported, Graves' disease is one of the rarer diseases. There are some reports that vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cause ASIA. Here, we describe a case of Graves’ disease following SARS-CoV-2 vaccination and a review of the literature. Case presentation A 41-year-old woman was admitted to our hospital because of palpitations and fatigue. Two weeks after receiving the second SARS-CoV-2 vaccine (BNT162b2, Coronavirus Modified Uridine messenger RNA (mRNA) Vaccine, Pfizer), she developed fatigue and gradually worsened. On admission, she exhibited thyrotoxicosis (thyroid-stimulating hormone (TSH) | 0.01 mIU/L (0.08–0.54), free triiodothyronine (FT3) 33.2 pmol/L (3.8–6.3), and free thyroxine (FT4) 72.1 pmol/L (11.6–19.3)) and palpitations associated with atrial fibrillation. TSH receptor antibody (TRAb) was positive (TRAb 5.0 IU/L (| 2.0)), and 99mTc scintigraphy showed diffuse uptake in the thyroid gland, suggesting that the thyrotoxicosis in this case was caused by Graves’ disease. Thiamazole was prescribed to correct her condition, and soon after this treatment was initiated, her symptoms and thyroid hormone levels were significantly reduced. Conclusions This case report reinforces the potential correlation between ASIA affecting the thyroid and SARS-CoV-2 mRNA vaccines. The clinical course suggests that it is essential to consider the possibility of developing ASIA, such as Graves' disease, after exposure to the SARS-CoV-2 vaccine.
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Eating disorder and self-harm diagnosis surged during the COVID-19 pandemic: an urgent need for interventionEating disorder and self-harm diagnosis surged during the COVID-19 pandemic: an urgent need for intervention LancetChildAdol OfficialUoM covid COVID19 SARSCoV2 eatingdisorders selfharm mentalhealth publichealth
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Boston Medical Center team chosen to redevelop Jamaica Plain Hospital CampusThe state on Wednesday announced that Boston Medical Center has been provisionally designated to lead the redevelopment of the sprawling Lemuel Shattuck Hospital Campus on Morton Street in Jamaica Plain. The BMC team’s initial proposal calls for two facilities with 326 treatment beds, 200 units of permanent supportive housing, 205 units of family supportive housing, 120 emergency housing beds, and…
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Wearable sweat sensor detects molecular hallmark of inflammationThe vast majority of diseases and disorders afflicting humans, ranging from arthritis to Zika fever, involve some level of inflammation. While inflammation is most familiar to us as pain, redness, and swelling, a slew of biochemical markers is associated with it as well.
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Roles of bile acids signaling in neuromodulation under physiological and pathological conditions - Cell & BioscienceBile acids (BA) are important physiological molecules not only mediating nutrients absorption and metabolism in peripheral tissues, but exerting neuromodulation effect in the central nerve system (CNS). The catabolism of cholesterol to BA occurs predominantly in the liver by the classical and alternative pathways, or in the brain initiated by the neuronal-specific enzyme CYP46A1 mediated pathway. Circulating BA could cross the blood brain barrier (BBB) and reach the CNS through passive diffusion or BA transporters. Brain BA might trigger direct signal through activating membrane and nucleus receptors or affecting activation of neurotransmitter receptors. Peripheral BA may also provide the indirect signal to the CNS via farnesoid X receptor (FXR) dependent fibroblast growth factor 15/19 (FGF15/19) pathway or takeda G protein coupled receptor 5 (TGR5) dependent glucagon-like peptide-1 (GLP-1) pathway. Under pathological conditions, alterations in BA metabolites have been discovered as potential pathogenic contributors in multiple neurological disorders. Attractively, hydrophilic ursodeoxycholic acid (UDCA), especially tauroursodeoxycholic acid (TUDCA) can exert neuroprotective roles by attenuating neuroinflammation, apoptosis, oxidative or endoplasmic reticulum stress, which provides promising therapeutic effects for treatment of neurological diseases. This review summarizes recent findings highlighting the metabolism, crosstalk between brain and periphery, and neurological functions of BA to elucidate the important role of BA signaling in the brain under both physiological and pathological conditions.
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