The maternal and perinatal outcomes of pregnancies complicated by monkeypox infection ajogmfm pregnancy pregnant monkeypox virus monkeypoxvirus infection disease
By Tarun Sai LomteSep 19 2022Reviewed by Danielle Ellis, B.Sc. In a recent study published in the American Journal of Obstetrics and Gynecology Maternal-Fetal Medicine , researchers evaluated the perinatal and maternal outcomes of pregnancies complicated by infection with the monkeypox virus.
About the study In the present study, researchers systematically reviewed and meta-analyzed the perinatal and maternal outcomes of pregnant individuals with MPX infection. The authors searched Cochrane, Embase, and Medline databases using relevant keywords, medical subject heading terms, and word variants for pregnancy and monkeypox. Search and selection of publications were restricted to the English language. Retrospective and prospective studies were included.
Findings Related StoriesOf over 2,400 articles identified initially, 15 were assessed based on inclusion criteria, and four were selected for systematic review. The four studies had seven cases with MPX during pregnancy and were from endemic countries . All subjects contracted MPX during their first or second trimester and required hospitalization.
Overall, the perinatal/fetal loss incidence was 77%, and only 23% of fetuses survived. The incidence of pre-term births before 37 gestational weeks was 8%. The overall incidence of vertical transmission was 62%, albeit this assessment was impeded by fetal losses that occurred early in the second trimester and the lack of PCR analysis on the aborted tissue. Overall, fetal loss incidence was 67% following the first trimester and 82% among those with MPX in the second trimester.
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