The neural mechanisms causing long-COVID fatigue braincomms UniofNewcastle FAU_Germany longcovid fatigue neuroscience postcovidconditon postcovidfatigue neural research covid COVID19 SARSCoV2
By Pooja Toshniwal PahariaApr 14 2023Reviewed by Lily Ramsey, LLM In a recent study published in the Brain Communications Journal, researchers investigated the neural mechanisms underlying post-coronavirus disease fatigue .Background COVID 2019 symptoms may persist beyond the acute phase of the disease [referred to as long COVID or post-COVID-19 condition ].
For comparison, 52 sex- and age-matched individuals without fatigue were included, among whom six had suffered from mild COVID-19 and recovered from it without pCF. Further, high-density-type surface electromyography was performed to evaluate muscle motor units’ activity, from which the neuromodulatory system metrics were derived.
The mean FIS score among pCF patients was 83, indicating that fatigue moderately impacted daily lives. The duration between COVID-19 diagnosis and laboratory testing for SARS-CoV-2 was 121 days. No correlation was observed between fatigue severity and days elapsed since the SARS-CoV-2 infection. Indicating that pCF patients develop metabolic alterations in muscle fibers following prolonged activities that result in lowered force output. Post-COVID fatigue patients had normal grip strength, without any evidence of fatiguing transmission at the neuromuscular junction , and normal intrinsic excitability of motoneurons.
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