What is the next big thing in cancerresearch? Experts across the globe provide their insights.
"It is astonishing to realize that very little research has been done to investigate the long-term reproductive or fertility consequences of new agents we investigate in the phase 3 setting and then prescribe routinely in the curative setting," Loi said.C.S. Pramesh, MS, FRCS, director of the Tata Memorial Hospital in Mumbai, India, believes that cancer research should prioritize global experiences, instead of focusing so heavily on high-income countries such as the United States.
"With much of the cancer burden likely to fall on low- and middle-income countries, it seems incongruous that almost 90% of cancer research currently takes place in high-income countries," Pramesh said."Neither the discordance between the cancer burden and research funding in high-income countries nor the types of problems or solutions addressed in these countries are relevant to the majority of patients with cancer in the world.
"Now is the time for the global community to wake up, take notice, and change the direction of cancer research for the larger public good," Pramesh said.The next big focus in cancer research should be to develop effective combination therapies, according to René Bernards, PhD, from The Netherlands Cancer Institute.
"Resistance to therapy remains a major obstacle in the treatment of cancer," Bernards said. But, as the AIDS pandemic has taught us, the use of multiple drugs with"nonoverlapping resistance mechanisms can make a deadly disease with a high mutation rate chronic."
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