This article explores the possibilities of stem cell therapies.
Sponsored Content by Corning Life SciencesNov 22 2022Reviewed by Olivia Frost Stem cell research has significantly increased over the past few years, as shown by activity in the lab and clinic and investments made across the industry.
For lab scientists trying to realize the potential of stem cell therapies while avoiding the many pitfalls, new technologies, culturing platforms, and materials have reduced costs, obligations, and pressures. That strategy is frequently tailored to fit the particulars of the cell type, such as pluripotent cells or multipotent or unipotent adult stem cells .
Operational considerations, such as labor or equipment costs and time to market, go along with these scale-up options. Teams will be best prepared for a successful and timely scale-up if they choose their surfaces carefully and cautiously. We have seen that adult mesenchymal cells are comparatively easier to grow because they have less sensitivity to not having an extracellular matrix , while more complex cells, like induced pluripotent or embryonic stem cells, may need the signaling and structure of an ECM, such as Corning® Matrigel® matrix or a more defined biological relevant substrate such as Corning rLaminin-521. So much can be optimized according to these unique cell types.
“You want to develop a very efficient seed train that can yield as many cells as you can while replicating them as few times as you can. That is because one of the big challenges with some stem cells, such as mesenchymal stem cells, is that after you isolate them, they can only replicate a limited number of times in vitro,” Bongiorno added.
Products that are exclusively optimized for organoid cultures or those that are hESC-qualified can sometimes fall under this category. With developing fields such as electric vehicle production and acellular therapies, in addition to the potential for producing EVs in MSCs and other stem cells4, it is crucial that what occurs in whole tissues and organs is accurately represented as researchers move from 2D cultures to 3D models.
Seed train compatibility An effective scale-up strategy requires that the various components of the seed train remain compatible and consistent. For instance, it is ideal if the surface treatment used on a smaller vessel, such as a single-layer flask, remains the same as production increases. Through this upstream work, time and money can be saved downstream.
Such systems prevent opportunities for contamination by limiting how frequently or how long platforms are exposed to the environment.
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