The relationship between neutralization levels and observed efficacies against asymptomatic and symptomatic infection of ten COVID-19 vaccines medrxivpreprint UTAustin Cambridge_Uni vaccine vaccination COVID19 coronavirus covid
By Neha MathurNov 24 2022Reviewed by Danielle Ellis, B.Sc. In a recent study posted to the medRxiv* server, researchers determined whether neutralizing antibody levels were predictive of the efficacy of fractional vaccine doses against severe acute respiratory syndrome coronavirus 2 infection.
About the study In the present study, researchers first performed a systematic review of 51 peer-reviewed studies on within-host models of SARS-CoV-2 in PubMed on 15 March 2022. They extracted relevant information related to vaccines and participants from the 13 selected studies. They analyzed the relationship between in-vitro NAb neutralization levels and the VEs of 10 COVID-19 vaccines against SARS-CoV-2 infection.
Study findings The researchers identified 2811 studies through an electronic search on PubMed and excluded 2777 duplicates. They screened the full text of 83 studies, from which only 51 met the inclusion criteria of the current systematic review. Further, they compiled 13 records from Pubmed of VE against asymptomatic and symptomatic infection by 11 COVID-19 variants and 10 types of vaccines . The rooted mean square error for the predicted VE for asymptomatic and symptomatic infection was 2.
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