A Review in Molecular Neurodegeneration discusses the clinical and translational research on the connection between acute inflammatory insults and Alzheimer’s disease and the therapeutic approaches that may be used following inflammatory insults.
In the section that follows, we provide a roadmap for future research efforts directed at understanding the role that peripheral inflammatory insults may play in AD pathogenesis, and developing interventions to limit the deleterious effect these inflammatory stressors may have on brain health .
Extending this further, burgeoning evidence points to changes in the adaptive immune system in aging adults and adults with AD, with recent data showing that a portion of clonally expanded CD8 + T-cells in AD patients may be specifically reactive to the Epstein-Bar virus []; although outside the scope of this Roadmap paper, it will be important to clarify how acute inflammatory insults relate to chronic or latent infections, how acute infectious and non-infectious inflammatory insults impact...
Finally, another understudied area of research on acute inflammatory insults is how sex-based differences in immune response might serve as potential contributors to AD risk.
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