Researchers discuss current therapeutic interventions for atopic dermatitis in children and adolescents.
By Dr. Sanchari Sinha Dutta, Ph.D.Aug 21 2023Reviewed by Benedette Cuffari, M.Sc. In a recent review published in Frontiers in Medicine, researchers discuss current therapeutic interventions for atopic dermatitis in children and adolescents.
Therapeutic management of atopic dermatitis The first-line treatment for atopic dermatitis in children and adolescents is topical corticosteroids. The early use of high-potency corticosteroids at the onset of acute disease helps control inflammation, regenerate the skin barrier, and reduce long-term use of the medication. In skin areas with higher absorption, such as the eyelids, genitals, and face, low-to-moderate potency corticosteroids are generally applied.
Oral corticosteroids like methylprednisolone are used for flares or severe disease. Long-term use of oral corticosteroids can cause suppression of the hypothalamic-pituitary-adrenal axis, hypertension, weight gain, osteoporosis, and growth impairment in children. This dosage may induce infection, nephrotoxicity, hypertension, tremor, hypertrichosis, headache, gingival hyperplasia, skin cancer, and lymphoma. For non-severe disease, a dose of 2.5-5 mg/kg/day split into two doses is advised.
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