Three-drug combination therapy effective in patients with high-risk chroniclymphocyticleukemia, trial shows danafarber
The initial cohort of the trial, which included patients with any subtype of CLL, found that a regimen of acalabrutinib, venetoclax, and obinutuzumab produced deep remissions in 89% of participants. The new cohort, which exclusively included patients with high-risk CLL, found a similar deep-remission rate of 83%.
The study's lead author, Christine Ryan, MD, of Dana-Farber, will present the findings at the American Society of Hematology Annual Meeting on Saturday, December 10. The trial, conducted at Dana-Farber, Beth Israel Deaconess Medical Center, Stamford Hospital, and Lifespan Health System, in Rhode Island, involves 68 patients with previously untreated CLL, 41 of whom have a mutation and/or deletion in the TP53 gene in their
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