Men whose symptoms improved with medication in a clinical trial were less likely to die during follow-up.
The average reduction in symptom score at 4 years was 4.9 with placebo, 6.6 with doxazosin, 5.6 with finasteride, and 7.4 with combination therapy. Active treatment reduced symptoms significantly more than placebo .
"This effect was quite pronounced: the hazard of death decreased by 12% if the AUA Symptom Score decreased by 3 points," they report. Since MTOPS was conducted, doxazosin, which can be used to treat hypertension, has become less commonly used to treat urinary symptoms as clinicians have turned to other medications that do not require titration, Welk said.
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