October is BreastCancerAwareness month. Read the latest clinical news on this topic.
and performed two-sample Mendelian randomization — a study method that assesses causality by using genetic variants as proxies for particular risk factors. In this study, genetic variants were used as proxies for lifelong physical activity levels and sedentary behaviors.
Patients with greater genetic predisposition to higher overall activity levels had a 41% lower overall breast cancer risk . Genetically predicted vigorous activity was associated with a 38% lower risk for premenopausal and perimenopausal breast cancer . In contrast, greater genetically predicted sedentary time was associated with a 77% higher risk for hormone receptor–negative breast cancer risk , including triple-negative breast cancer , for which the risk was 104% higher .
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