The study, Recover, aims to complete enrollment of 40,000 people and launch clinical trials on potential treatments by the end of the year.
The U.S. government is rolling out a massive study of long Covid in an effort to understand the mysterious condition.The National Institutes of Health also plans to launch clinical trials on potential treatments in coming months.Scientists, physicians and public health officials are worried millions of Americans may have long-term health complications from Covid-19.
Dr. Walter Koroshetz, who serves on Recover's executive committee, said the study has been designed to investigate long Covid from every possible angle and provide definitive answers. But Koroshetz acknowledged that even a study this size will face major challenges in delivering on such ambitious goals.
The National Institutes of Health is also planning to launch a "suite of clinical trials" on possible treatments in the coming months, according to Dr. Gary Gibbons, director of the National, Heart Lung and Blood Institute. Gibbons said NIH is in active discussions with the pharmaceutical industry on studying whether antivirals and other interventions can prevent or treat long Covid.
Scientists still do not know how the virus triggers such a wide spectrum of symptoms that can persist months after the initial infection, why some of these symptoms show up in some patients but not in others, or what exactly the risk factors are for developing them. The nation's health agencies do not yet know exactly how many people suffer from the condition. The answer to that question, which Recover hopes to shed more light on, could have major implications for the nation's health and economy.that examined nearly 2 million patient records, found that one in five Covid survivors ages 18 to 64 and one in four ages 65 and older developed a health problem that could be related to long Covid.
All the participants in Recover will undergo a battery of lab tests, vital signs and physical assessments, as well as a survey of symptoms and underlying health conditions among many other questions at enrollment and at regular intervals throughout the study. Smaller populations of participants will undergo more intense evaluations that include electrocardiograms, brain MRIs, CT scans and pulmonary function tests.
Dr. Grace McComsey, the principal investigator for the Recover site at Case Western Reserve University in Cleveland, said the study design will allow her team to access a large pool of patient data that they otherwise wouldn't have the time or resources to collect on their own. McComsey, an infectious disease expert who researched HIV before the pandemic, has submitted a concept with her team to look at how the virus is causing inflammation in patients.
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