A previously unknown mechanism that drives aging has been found to be universal across a range of different animals, including humans. A new study finds that most molecular-level changes that occur during aging are associated with gene length Organisms balance the activity of short and long
The discovery could open the door to interventions aimed at slowing down or even reversing the aging process.
Findings could lead to medical interventions that slow or even reverse the biological hallmarks of aginghas uncovered a previously unknown mechanism that controls aging. The new finding potentially could lead to interventions designed to slow the pace of — or even reverse — aging. The study was recently published in the journal“The changes in the activity of genes are very, very small, and these small changes involve thousands of genes,” said Northwestern’s Thomas Stoeger, who led the study. “We found this change was consistent across different tissues and in different animals. We found it almost everywhere.
“There already seems to be something happening early in life, but it becomes more pronounced with age,” Stoeger said. “It seems that, at a young age, our cells are able to counter perturbations that would lead to an imbalance in gene activity. Then, suddenly, our cells are no longer able to counter it.”
“We have been primarily focusing on a small number of genes, thinking that a few genes would explain the disease,” Amaral said. “So, maybe we were not focused on the right thing before. Now that we have this new understanding, it’s like having a new instrument. It’s like Galileo with a telescope, looking at space. Looking at gene activity through this new lens will enable us to see biological phenomena differently.
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