Throughout the COVID-19 pandemic, the range of clinical outcomes for individuals infected with SARS-CoV-2 varied widely, from showing no symptoms to succumbing to the disease. A research team from the Institut Pasteur, the CNRS, and the Collège de France collaborated with international scientists to
, and the Collège de France collaborated with international scientists to study the variations in immune responses to SARS-CoV-2 among populations in Central Africa, Western Europe, and East Asia.
Scientists have identified around 900 genes that respond differently to SARS-CoV-2 between populations. Using statistical genetic analyses, they show that these disparities are mainly due to variations in blood cellular composition: the proportion of each cell type differs from one population to another.
Furthermore, the scientists have identified around 1,200 human genes whose expression in response to SARS-CoV-2 is under the control of human genetic factors and the frequency of the alleles that regulate these genes can vary between the populations studied. Using population genetics approaches, they have identified recurrent selection events targeting genes involved in anti-viral functions.
Between 1.5% and 2% of the genomes of Europeans and Asians is of Neanderthal origin. There is growing evidence of links between Neanderthal ancestry and present-day immunity to infection. By comparing the 1,200 genes identified with the Neanderthal genome, the scientists have discovered dozens of genes that both alter antiviral mechanisms and result from ancient introgression between Neanderthals and modern humans .
Australia Latest News, Australia Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Unlocking the secrets of cilia: NSL complex regulates intraciliary transport systemCilia are thin, eyelash-like extensions on the surface of cells. They perform a wide variety of functions, acting as mechanosensors or chemosensors, and play a crucial role in many signaling pathways.
Read more »
When proteins get stuck at solid: unlocking the secrets to brain diseasesBiomedical engineers have developed sophisticated optical techniques to monitor at close range the process by which protein aggregates form during liquid-to-liquid transition. This can lead to solid condensates which can trigger a process that forms neural plaques, that can cause Alzheimer's and other diseases.
Read more »
Council Post: Unlocking Audience Insights: Harnessing The Power Of Data To Understand Your UsersData is a powerful tool for understanding your audience, informing decision making and driving business growth.
Read more »
Council Post: Artificial Intelligence In Cybersecurity: Unlocking Benefits And Confronting ChallengesAI has the potential to revolutionize cybersecurity.
Read more »
Unlocking Value: EV Fast Charger Integration at Car DealershipsAs the electric vehicle revolution moves forward, EV fast charger integrations at car dealerships are becoming must-have items!
Read more »
8 Yellowstone Secrets From National Park RangersFrom the spots you didn't even know existed to how you could be arrested, national park rangers reveal their Yellowstone secrets.
Read more »