The new technique is “like upgrading from the Hubble to the James Webb.” A new imaging technique captures the three-dimensional architecture of the human genome with unprecedented detail, showing how individual genes fold at the level of nucleosomes, the fundamental units constituting the genome’s
The new technique is “like upgrading from the Hubble to the James Webb.”
The new technique allows researchers to create and digitally navigate three-dimensional models of genes, seeing not just their architecture but also information on how they move or how flexible they are. Understanding how genes function might help us better understand how they influence the human body in both health and disease since almost every human disease has some genetic basis.
The technology is the next evolution of imaging techniques used to study living organisms, which first started more than four hundred years ago with the creation of microscopes. These played a crucial role in advancing medicine and human health, for example, used by Robert Hooke to describe cells for the first time and later used by Santiago Ramón y Cajal to identify neurons.
Super-resolution microscopy changed the course of biomedical research, enabling scientists to track proteins in a variety of diseases. It also enabled researchers to study molecular events that regulate gene expression. Scientists now want to build on the technology and take it one step further by adding more layers of information.
From left to right: Pia Cosma, Laura Martin, Rafael Lema, Ximena Garate, Victoria Neguembor, Pablo Dans, Juan Pablo Arcon, Jürgen Walther, Isabelle Brun Heath, Pablo Romero, Diana Buitrago. Credit: BISTsequencing techniques and super-resolution microscopy to provide an essential picture of the 3D shape of genes at resolutions beyond the size of nucleosomes, reaching the scales needed to understand in detail the interaction between chromatin and other cell factors,” says Dr.
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