The kidney was provided from a pig that had been genetically edited to remove genes that could be harmful to a human recipient and add certain human genes to improve compatibility.
A 62-year-man with end-stage renal disease has become the first human to receive a new kidney from a genetically modified pig, doctors from Massachusetts General Hospital in Boston announced on Thursday. The four-hour surgery, performed on March 16, "marks a major milestone in the quest to provide more readily available organs to patients," the hospital said in a statement.
Drugs used to help prevent rejection of the pig organ by the patient's immune system included an experimental antibody called tegoprubart, developed by Eledon Pharmaceuticals ELDN.O. The surgery marks progress in xenotransplantation – the transplanting of organs or tissues from one species to another - said Dr. Robert Montgomery, director of the NYU Langone Transplant Institute, who was not involved in the case.
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