Wearable skin patch could help clinicians diagnose tumors, organ malfunction and more Hemoglobin Skin Wearables ucsandiego NatureComms
By Dr. Liji Thomas, MDDec 22 2022Reviewed by Benedette Cuffari, M.Sc. Electronic wearable patches have been devised to monitor various health conditions by noninvasively detecting biomolecules on the skin surface.
Introduction Biomolecules in the body can be used to monitor health and disease states and assess the outcomes of certain treatments. The amount and location of hemoglobin in the body, for example, is key to determining how well various tissues and organs are perfused and the accumulation of blood in that area.
What does the study show? The photoacoustic patch comprises several different ultrasonic transducers that detect acoustic waves and vertical-cavity surface-emitting laser diodes. Both types are integrated on a common substrate composed of an elastomeric matrix and are linked to each other by coiled metal electrodes.
This wavelength is consistent with the dominant optical absorption coefficient of hemoglobin. VCSEL diodes at this wavelength are commonly available due to low attenuation in fibers, with silicon diodes at 850 nm often inexpensive and broadly employed. The loss of detection sensitivity of the transducers is less than -10 dB, thus indicating that the patch has high imaging depth and uniform sensitivity. This allows for a detailed, high-resolution, and 3D map of hemoglobin to be produced.
[This photoacoustic imaging] takes advantages of the unique absorption characteristics of biomolecules and highly penetrating acoustic waves to achieve high spatial resolution mapping of biomolecules in deep tissues.”
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