Weight-loss drugs can improve kidney health, study finds

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Weight-loss drugs can improve kidney health, study finds
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Analysis involving more than 85,000 people showed risk of worsening function was reduced by 22%

Weight-loss drugs can reduce the risk of worsening kidney function, kidney failure and dying from kidney disease by a fifth, according to a study.

But while the benefits of the drugs for treating obesity, type 2 diabetes and cardiovascular disease are well known, their potential impact on kidney health has been less certain. Compared with placebo, GLP-1 receptor agonists reduced the risk of kidney failure by 16% and the worsening of kidney function by 22%, researchers said. The combined reduction in the risk of kidney failure, worsening kidney function and death due to kidney disease was 19%., with a 14% reduction in the risk of cardiovascular death, non-fatal heart attack and non-fatal stroke, compared with placebo. Death by any cause was 13% lower among patients treated with GLP-1 receptor agonists.

“These results are particularly important for patients with chronic kidney disease. It is a progressive condition eventually leading to kidney failure requiring dialysis or kidney transplantation and is associated with premature death, mostly from heart disease. It has a significant impact on patients’ quality of life and incurs substantial healthcare costs.”

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