What is currently known about the mechanism and treatments of long COVID? PNASNews longcovid coronavirus covid COVID19
By Dr. Chinta SidharthanSep 6 2022Reviewed by Danielle Ellis, B.Sc. A recent feature published in PNAS discussed the current understanding of the mechanisms underlying long coronavirus disease or post-acute sequelae of COVID and potential treatment methods that show promise in long COVID management.
About the feature The present piece reports the headway made in the two years since the onset of the COVID-19 pandemic in understanding the mechanisms of long COVID. Researchers investigating PASC believe it results from various COVID-19 complications, including tissue damage and lingering virus and viral particles that could trigger inflammatory and autoimmune responses.
Related StoriesWhile hidden SARS-CoV-2 virus and viral particle reservoirs would explain many of the persistent and recurring symptoms of PASC, biopsies are necessary to test for the presence of viral RNA in tissues. This makes the hidden viral reserve hypothesis difficult to prove since biopsies are invasive and much more expensive than nasal swabs.
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