What is currently known about the mechanisms by which DNA tumor viruses evade uracil-mediated antiviral immunity? PLOSPathogens UNC DNA tumor immunity cancer oncology vrius antiviral
By Dr. Chinta SidharthanApr 3 2023Reviewed by Danielle Ellis, B.Sc. In a recent study published in PLOS Pathogens, researchers reviewed the existing knowledge on the mechanisms through which deoxyribonucleic acid tumor viruses evade the antiviral immunity mediated through mis-incorporated uracil .
Furthermore, while the restriction of RNA tumor viruses by the A3 proteins is not known to be uracil-mediated, the uracil-mediated antiviral immune mechanisms against DTVs through the AID and A3 protein families have been of considerable interest in recent times. The genomes of DTVs are much smaller than the human genome and do not comprise genes for repair proteins that can excise and remove the uracil bases incorporated by the AID and A3 enzymes. The excision of uncoordinated uracil bases from the DTV genomes leads to an accumulation of abasic sites and subsequent degradation of the viral genome, which is known as uracil-mediated antiviral immunity.
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