What is the association of SARS-CoV-2 vaccination with the risk of PASC in patients with SARDs? medrxivpreprint MassGeneralNews BrighamWomens harvardmed SARSCoV2 COVID19 coronavirus covid vaccination vaccine
By Nidhi Saha, BDSOct 11 2022Reviewed by Danielle Ellis, B.Sc. Findings of a new study posted on medRxiv* preprint server depicted that fully vaccinated patients with systemic autoimmune rheumatic diseases harbor a lower propensity to developing long COVID symptoms compared to SARDs patients who are not fully vaccinated.
The probability of developing PASC is influenced by the severity of the acute infection. Individuals with systemic autoimmune rheumatic diseases are at an increased risk of developing severe COVID-19. Additionally, due to the compromised immunity, this group of patients is likely to respond inadequately to vaccines, further accentuating their chances of developing PASC.
The study was conducted in a multicenter healthcare facility , including two tertiary hospitals, twelve community hospitals, and the associated outpatient centers in Massachusetts. A nasopharyngeal swab test or polymerase chain reaction -confirmed SARS-CoV-2 infected individuals at least 18 years of age were selected between March 2020 to July 2022. All selected patients also had been diagnosed with rheumatic disease. SARD diagnoses were also reconfirmed.
The participants were enrolled 28 days post a confirmed COVID-19 positive test result. Patients who had completed 90 days of the survey post-COVID-19 diagnosis were analyzed for the definition of SARD according to the WHO. Among SARD categories, inflammatory arthritis was the most common. Disease-modifying anti-rheumatic drugs , most frequently used during COVID-19 were – hydroxychloroquine, methotrexate, and mycophenolate. The most common targeted synthetic and biologic DMARDs were tumor necrosis factor inhibitors, Janus-kinase inhibitors , and anti-CD20 monoclonal antibodies.
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