What is the impact of antibiotic exposure on the risk of inflammatory bowel disease? Gut_BMJ nyugrossman IcahnMountSinai antibiotics antibiotic IBD inflammation inflammatoryboweldisease disease
By Pooja Toshniwal PahariaJan 12 2023Reviewed by Danielle Ellis, B.Sc. In a recent study published in Gut, researchers evaluated the impact of antibiotic usage on inflammatory bowel disease development risk among individuals aged ten years and above.
Demographic data were obtained from the national CRS of Denmark on individuals aged ≥10 years, residing in Denmark for ≥5.0 years, and having no IBD history between January 1, 2000, and December 31, 2018. Data on prescribed medications were obtained from the Danish national prescription register in linkage with the civil registration system. Medications were coded based on the anatomical therapeutic chemical system.
The national patient register of Denmark was utilized to obtain data on hospitalizations, outpatient and emergency department visits. IBD diagnosis was based on the ICD-8/10 codes. Results Immunology eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy The study population comprised 6,104,245 individuals, followed up for 87,112,328 individual-years. Among the participants, 5,551,441 individuals had been prescribed ≥1.0 courses of antibiotics, and 52,898 new IBD cases were documented.
The greatest risk of IBD development was observed after one to two years of antibiotic use, and with every subsequent year, the risk was reduced. Particularly, for persons aged between 10 and 40 years, the IRR values were 1.4 one to two years post-antibiotic exposure and 1.1 four to five years post-exposure. Likewise, for persons aged between 40 years and 60 years, the IRR values were 1.7 one to two years post-antibiotic use and 1.2 four to five years post-use.
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