What is the role of SARS-CoV-2 non-structural protein 2 in repressing host antiviral immunity? biorxivpreprint QUBelfast SARSCoV2 COVID19 Coronavirus HostAntiviralImmunity
By Neha MathurJan 5 2023Reviewed by Aimee Molineux In a recent study posted to the bioRxiv* server, researchers uncovered a novel mechanism that severe acute respiratory syndrome coronavirus 2 and other coronaviruses use to exploit host antiviral immune system to facilitate their replication.
Study findings Experiments with parental, GIGYF2-knockout , and 4EHP-KO HEK293 cells transfected with miR-20 wildtype or miR-20 mutated reporter mRNAs showed marked de-repression of both miRNAs in 4EHP-KO and GIGYF2-KO cells compared with the parental cells. It showed that miR-20a-mediated repression of target mRNA was dependent on GIGYF2/4EHP complex.
Also, there is a possibility that CoVs manipulate the expression pattern of antiviral miRNAs to avoid the potentially deleterious effects of NSP2-induced translation repression. Studies examining the expression of over 100 human miRNAs with the potential to affect the SARS-CoV-2 genome showed that their low expression in lung epithelial cells likely allowed CoVs to circumvent the antiviral effects of miRNAs facilitating their own replication inside the host cells.
NSP2-mediated control of miRNA-mediated translational repression during SARS-CoV-2 infection might have a substantial physiological impact. Thus, NSP2-originated peptides that preserve the GIGYF2/4EHP complex functionality could help modulate miRNA-mediated silencing, irrespective of SARS-CoV-2 infection.
Australia Latest News, Australia Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Longitudinal seroprevalence study among pregnant people indicates waning of immunity from natural SARS-CoV-2 infectionsLongitudinal seroprevalence study among pregnant people indicates waning of immunity from natural SARS-CoV-2 infections UW medrxivpreprint SARSCoV2 Pregnancy COVID19 Seroprevalence Immunity
Read more »
Researchers discover new type of CRISPR gene scissorsLike humans, bacteria and archaea can be attacked by viruses. These microorganisms have developed their own immune defense strategies against their pathogens. Bacterial defenses, such as CRISPR-Cas systems, have diverse proteins and functions that help bacteria protect themselves against foreign invaders.
Read more »
Chinese researchers claim success in breaking encryption using quantum computers\n\t\t\tKeep abreast of significant corporate, financial and political developments around the world.\n\t\t\tStay informed and spot emerging risks and opportunities with independent global reporting, expert\n\t\t\tcommentary and analysis you can trust.\n\t\t
Read more »
Researchers Identify blood panel to predict placenta accretaOf the nearly 4 million births each year in the United States, roughly 50,000 are marked by life-threatening complications, and up to 900 result in maternal death during delivery. One major, often life-threatening complication is placenta accreta spectrum (PAS), which poses a threat to both the mother and the baby. Currently, PAS cases are identified by ultrasounds, MRIs, and predictive confounding conditions—but these methods leave between 33% and 50% of PAS cases undetected prior to delivery. A new study by investigators from Brigham and Women's Hospital, a founding member of the Mass General Brigham healthcare system, embarked on a study to create a targeted test for predicting PAS during pregnancy, thus better preparing patients and practitioners for the delivery day. By studying circulating microparticle (CMP) protein panels in pregnant women, the team identified five unique CMP proteins that can predict PAS as early as the second trimester of pregnancy. Their results are published in Scientific Reports.
Read more »
COVID booster shots cut Omicron transmission in closed environmentsIn a recent paper published in the journal Nature Medicine, researchers in the United States investigated the infectiousness of incarcerated individuals with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron infections in prisons, high-risk settings where transmission is intense.
Read more »
The relationship between metabolic disease and alternations in lipid homeostasisThe relationship between metabolic disease and alternations in lipid homeostasis ICS_Seville SaludISCIII metabolicdisease disease lipid homeostasis fat
Read more »