Scientists have grown embryo-like models using monkey stem cells for the first time, which when implanted in surrogate monkey 'mothers' appear to progress through the earliest stages of gestation.
A quarter of the experiment's stem cells progressed into a blastoid form, a success rate on par with previous experiments using human embryonic stem cells. These were then cultured in a lab until they began to form three distinct layers in a process known as gastrulation, a key moment in embryonic development that sets up a basic body plan. Several of these blastoids progressed to form a yolk sac and amnion .
The scientists selected blastoids that had been cultured for seven days, which had an inner and outer cell mass and a visible cavity, since these are key features of natural embryos. Each surrogate monkey was 'impregnated' with 8 to 10 blastoids and monitored using ultrasounds and hormone testing over the next 20 days.
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