Nearly one million people in the United States are living with Parkinson's disease, making it the second-most common neurodegenerative disease after Alzheimer's.
Reviewed by Lily Ramsey, LLMAug 21 2023 Current medical treatments for Parkinson's are focused on helping people manage symptoms. But the underlying mechanisms of the neurological disorder remain poorly understood.
Using zebrafish models Weissman's work is focused on alpha-synuclein, the abnormally clumping protein found in the brains of Parkinson's patients. The National Institutes of Health is funding her innovative approach, which examines how this protein behaves in zebrafish models. She and her team are looking at the factors surrounding the phosphorylation at a protein site known as serine 129.
"Our question is, 'What else, in addition to the tag, needs to be in place for the clumping to occur?'" says Weissman.
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