A novel approach to quantify personal information contained within gut metagenome data NatureMicrobiol gutmicrobiome information metagenome data
By Neha MathurMay 17 2023Reviewed by Lily Ramsey, LLM In a recent study published in Nature Microbiology, researchers used shotgun sequencing to extract human reads from deoxyribonucleic acid in fecal samples of 343 Japanese individuals comprising the main dataset of this study.
This technology allows the sequencing of the non-bacterial component of the microbiome samples, including host DNA. For instance, in fecal samples, the amount of host DNA is less than 10% but is removed to protect the privacy of donors. Since this data could help quantitatively and precisely reconstruct genotype information, it could complement human WGS data.
The multi-ancestry dataset, which helped the researchers validate ancestry prediction analysis, comprised 73 individuals of various nationalities, including samples from individuals in New Delhi, India. In human microbiome and genetic research, the feasibility of sex prediction using human gut metagenome data could help remove mislabelled samples.
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