Acute kidney injury in hospitalized COVID-19 patients FrontiersIn Hopitaux_unige COVID19 SARSCoV2 Coronavirus AcuteKidneyInjury
By Bhavana KunkalikarOct 7 2022Reviewed by Aimee Molineux In a recent study published in the Frontiers in Medicine journal, researchers examined the phenotypes of acute kidney injury in hospitalized coronavirus disease 2019 patients.
To group AKI patients based on their pattern of risk variables, the team performed a retrospective, single-center cohort analysis to identify factors related to the emergence of AKI. All COVID-19 patients hospitalized in the ICU in the Geneva University Hospitals were screened from March through December 2020 as part of the trial. Patients were eligible for the study if they were older than 18 years and were not receiving chronic dialysis.
Unsupervised clustering was employed as the basis for the study method to detect subgroups of AKI patients. The team created a three-step pipeline of analysis on the raw dataset. To uncover characteristics strongly linked to the development of AKI in ICU patients, first, a nonlinear statistical model was constructed to determine the significance of each indicator for AKI risk at the individual patient level.
The final multivariable model found seven factors that were significantly linked to the development of AKI in the ICU: use of LPV/r that started prior to ICU admission, invasive mechanical ventilation required at ICU admission, and diabetes mellitus. On the other hand, dexamethasone administration at ICU admission was considered protective. A nonlinear relationship between AKI and the APACHE score, the FiO2 at ICU admission, as well as the eGFR at hospital entry was also observed.
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