'Our findings underscore the importance of identifying modifiable risk factors as early in life as possible -- and that the processes by which air pollution affects risk for later-life cognitive decline begins earlier than previous studies suggest.'
Three years ago, an international study commissioned by the journal Lancet listed 12 modifiable factors that increased the risk of dementia, including three new ones: excessive alcohol, head injury and air pollution.
Senior author William Kremen, professor of psychiatry and co-director of the Center for Behavior Genetics of Aging at the UCSD School of Medicine, and colleagues studied the men with a baseline age of 56, with 12 years of follow-up.Sign up for NBC Philadelphia newsletters. The genotype -- known as APOE -- has a version called APOE-4 that has been identified as a strong risk factor gene for Alzheimer's disease.
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