All-new BMC Kaius 01 gravel race bike is what you get when you cross a BMC Teammachine SLR aero road bike & a URS gravel bikepacking bike!
bikes. The aero gains and racy feel of the aero road racing bike. The big tire clearance, off-tarmac durability, and just enough compliance of the gravel adventure bike.BMC calls the new Kaius 01 the perfect blend for gravel racing.
From an aerodynamic perspective, the BMC Kaius strikes almost the exact profile as the Teammachine SLR – the only real exceptions being slightly deeper fork legs, a slightly sloping toptube, more robust seatstays, and a small rear wheel cutout to fit big tires into short chainstays. Tube shaping into the wind features the same chopped Kamm tail profiles.
And on the more off-road gravel rider comfort front, the bike can also get built up with BMC’s latest integrated cable routingThe Kaius gets a proprietary D-shaped aero seatpost but… The bike is compatible with 1x & 2x drivetrains and has a set of recessed top tube bolts for a clean bolt-on snack bag setup.BMC Kaius 01 – Pricing, options & availability
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Non-alcoholic fatty liver is associated with increased risk of irritable bowel syndrome: a prospective cohort study - BMC MedicineBackground The relationship between non-alcoholic fatty liver degree as well as non-alcoholic fatty liver disease (NAFLD) and irritable bowel syndrome (IBS) remains poorly understood. We aimed to investigate the prospective association of non-alcoholic fatty liver degree as well as NAFLD with incident IBS in a large-scale population-based cohort. Methods Participants free of IBS, coeliac disease, inflammatory bowel disease, alcoholic liver disease, and any cancer at baseline from the UK Biobank were included. Non-alcoholic fatty liver degree was measured by a well-validated fatty liver index (FLI), with FLI ≥ 60 as an indicator of NAFLD. Primary outcome was incident IBS. Cox proportional hazard model was used to investigate the associated risk of incident IBS. Results Among 396,838 participants (mean FLI was 48.29 ± 30.07), 153,203(38.6%) were with NAFLD diagnosis at baseline. During a median of 12.4-year follow-up, 7129 cases of incident IBS were identified. Compared with non-NAFLD, NAFLD patients showed a 13% higher risk of developing IBS (HR = 1.13, 95%CI: 1.05–1.17) after multivariable adjustment. Compared with the lowest, the highest FLI quartile was associated with a significantly increased risk of IBS (HRQ4 VS Q1 = 1.21, 1.13–1.30, Ptrend | 0.001). Specifically, the positive association between non-alcoholic fatty liver degree and IBS was also observed by per SD change of FLI (adjusted HR = 1.08, 1.05–1.10). Further sensitivity analysis and subgroup analysis indicated similar results, with the positive association particularly observed in females, but not in males. Conclusions High degree of non-alcoholic fatty liver as well as non-alcoholic fatty liver disease is associated with increased risk of incident IBS. Further studies are warranted to confirm the findings and elucidate the underlying biological mechanisms.
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Frailty in individuals with depression, bipolar disorder and anxiety disorders: longitudinal analyses of all-cause mortality - BMC MedicineBackground Frailty is a medical syndrome that is strongly associated with mortality risk and an emerging global health burden. Mental disorders are associated with reduced life expectancy and elevated levels of frailty. In this study, we examined the mortality risk associated with frailty in individuals with a lifetime history of mental disorders compared to individuals without a history of mental disorders. Methods The UK Biobank study recruited | 500,000 adults, aged 37–73, between 2006 and 2010. We derived the two most common albeit distinctive measures of frailty, the frailty phenotype and the frailty index. Individuals with lifetime depression, bipolar disorder or anxiety disorders were identified from multiple data sources. The primary outcome was all-cause mortality. We have also examined differences in frailty, separately by sex and age. Results Analyses included up to 297,380 middle-aged and older adults with a median follow-up of 12.19 (interquartile range=1.31) years, yielding 3,516,706 person-years of follow-up. We observed higher levels of frailty in individuals with mental disorders for both frailty measures. Standardised mean differences in the frailty index ranged from 0.66 (95% confidence interval [CI] 0.65–0.67) in individuals with anxiety disorders to 0.94 (95% CI 0.90–0.97) in individuals with bipolar disorder, compared to people without mental disorders. For key comparisons, individuals with a mental disorder had greater all-cause mortality hazards than the comparison group without mental disorders. The highest hazard ratio (3.65, 95% CI 2.40–5.54) was observed among individuals with bipolar disorder and frailty, relative to non-frail individuals without mental disorders. Conclusions Our findings highlight elevated levels of frailty across three common mental disorders. Frailty and mental disorders represent potentially modifiable targets for prevention and treatment to improve population health and life expectancy, especially where both conditi
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