Scientists believe they could double the survival of people with advanced cancer within a decade. World-leading cancer experts say cutting-edge research will mean more people get cured while others live far longer.
, and the Royal Marsden NHS Foundation Trust said cutting-edge research will mean more people get cured while others live far longer.
In one development, they hope to break the ability of cancer cells to instruct other cells in the body to come and support tumours. He said experts were already learning how they might use drugs that do not kill cancer directly, but which ‘instead talk to the immune system, increasing the function of those cells that are capable of attacking cancer cells and blunting or downregulating the functions of cells which naturally tend to protect the cancer cells’.
‘We plan to open up completely new lines of attack against cancer, so we can overcome cancer’s deadly ability to evolve and become resistant to treatment. Launching a joint five-year research strategy, Professor Kristian Helin, chief executive of the ICR, said: ‘We have created a really exciting plan to unravel and disrupt cancer’s ecosystems, with new immunotherapies, drugs to target the tissue environment, and clever new anti-evolution combinations and dosing strategies.
Australia Latest News, Australia Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Advanced cancer survival rates 'could double within a decade', say scientistsThe Institute of Cancer Research (ICR) says it has launched a 'really exciting' five-year research strategy which hopes to 'unravel and disrupt cancer's ecosystems'.
Read more »
Shropshire cancer charity gets £95k boost to ‘go mobile’ and boost cancer awarenessA brand-new exhibition van will be hitting Shropshire’s roads and towns as part of the fight to beat cancer – thanks to a generous £95,000 donation from a county business. Shropshire Charity LingenDavies
Read more »
PSG owner Al-Khelaifi says 'world is being unfair' to Qatar as World Cup startsParis Saint-Germain owner Nasser Al-Khelaifi has told talkSPORT the world is being ‘unfair’ to Qatar. The World Cup hosts have come under scrutiny for multiple human rights concerns from the treatm…
Read more »
Frontiers | Identification of a naturally-occurring canine model for early detection and intervention research in high grade urothelial carcinomaBackground: Early detection and intervention research is expected to improve the outcomes for patients with invasive urinary bladder cancer, specifically muscle invasive urothelial carcinoma (InvUC). With limited patients in suitable high-risk study cohorts, identifying relevant animal models for this research is critical. Experimental animal modes, while essential in InvUC research, often fail to adequately represent human cancer, and fail to predict drug responses. The purpose of this study was to define a naturally-occurring canine model for early intervention research by studying dogs with high breed-associated risk for InvUC, e.g. Scottish Terriers (STs). Methods: STs (n=120) ≥ 6 years old with no outward evidence of urinary disease were screened at 6-month intervals for 3 years. Screening included physical exam with digital rectal exam, ultrasonography, and urinalysis with sediment exam. Cystoscopic biopsy was performed in dogs with positive screening tests. The pathological, clinical, and molecular characteristics of the “early” cancer detected by screening were determined. Transcriptomic signatures were compared between the early tumors and published findings in human InvUC, and to more advanced “later” canine tumors from STs who had the typical clinical presentation of hematuria and urinary dysfunction. An early intervention trial of an oral cyclooxygenase inhibitor, deracoxib, was conducted in dogs with cancer detected through screening. Results: Biopsy-confirmed bladder cancer was detected in 32 (27%) of 120 STs including InvUC (n=29, three starting as dysplasia), grade 1 noninvasive cancer (n=2), and carcinoma in situ (n=1). Transcriptomic signatures including druggable targets such as EGFR and the PI3K-AKT-mTOR pathway, were very similar between canine and human InvUC, especially within luminal and basal molecular subtypes. Marked transcriptomic differences were noted between the early and later canine tumors, particularly within luminal subtype tumors.
Read more »
Scientists discuss using satellites to 'beam' solar energy collected in space to EarthSatellites could be operational by 2040, with the technology already being tested on a small scale.
Read more »