CAR T cell therapy could reach beyond cancer pennmedicine NatureMedicine CellCellPress
Engineered immune cells, known as CAR T cells, have shown the world what personalized immunotherapies can do to fight blood cancers. Now, investigators have reported highly promising early results for CAR T therapy in a small set of patients with the autoimmune disease lupus.
There are now six FDA-approved CAR T cell therapies in the United States, for six different cancers. The therapies have revolutionized the treatment of certain B cell leukemias, lymphomas, and otherFrom the start of CAR T research, experts believed that T cells could be engineered to fight many conditions other than B cell cancers.
In the German study, the patients—five young adults—did not benefit from standard lupus treatments. Yet, all went into remission, and were able to stop taking their lupus drugs within three months of a single, relatively small dose of CAR T therapy, which essentially removed their existing B cells.
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