A study led by King's College London compared the safety and efficacy of ciclosporin with methotrexate in children and young people with severe atopic dermatitis, a debilitating skin condition. They also examined whether the severity of the disease changed or returned after treatment ended.
for pediatric patients with this condition, and with new therapies being introduced at a high cost, establishing a gold standard for treatment with the conventional systemic therapies like methotrexate and ciclosporin is needed.
The trial assessed 103 children with severe atopic dermatitis age 2–16 years across 13 centers in the U.K. and Ireland. The patients were given oral doses of methotrexate or ciclosporin and assessed over nine months of treatment and six months after the therapy ended. The study found that ciclosporin works faster and reduces disease severity more at 12 weeks but was more expensive, whereas methotrexate was significantly cheaper and led to better objective disease control after 12 weeks and off therapy, with fewer participant-reported flares of atopic dermatitis after treatment had stopped. There were also no concerning safety signals.
The paper,"Efficacy and safety of ciclosporin versus methotrexate in the treatment of severe atopic dermatitis in children and
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