Does depression in caregivers affect the prognosis of Parkinson’s disease patients?

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Does depression in caregivers affect the prognosis of Parkinson’s disease patients?
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Researchers assessed the relationship between care providers with depressive symptoms and the quality of life, hospital admissions, and emergency department consultations of Parkinson’s disease patients.

By Pooja Toshniwal PahariaAug 17 2023Reviewed by Sophia Coveney In a recent study published in JAMA Network Open, researchers assessed the relationship between care providers with depressive symptoms and the quality of life , hospital admissions, and emergency department consultations of Parkinson’s disease patients.

Studies have reported that care provider strain is associated with increased motor symptoms, cognitive impairments, sleep disruptions, and a lack of reciprocity among PD patients. However, data on the impact of care providers’ health on PD patient outcomes are limited. In total, 454 PD patients and their care providers were enrolled during regular consultations with mobility disorder specialists by convenience sampling. The team included individuals diagnosed with PD by physicians who resided at their homes and had at least one follow-up visit within two years of study initiation.

Results In total, 663 patient-care provider dyads participated in the PF-POP care provider sub-study, of which 209 were excluded due to inadequate follow-up information, initial follow-up after two years of study initiation, or missing care provider data on depressive symptoms. As a result, 454 dyads were considered for the final analysis. The mean age of the PD patients was 67 years, and 320 were male, whereas the mean age was 66 years, and 326 were female.

Among PD patients, the mean CES-D score was 9.8, with scores of 22 and 6.6 among those with care providers who had depression risks and no depression risks, respectively. Patients who had care providers with no depression symptoms had higher verbal fluency scores than those who had care providers with depression symptoms.

Concerning annual hospital admissions, PD patients with care providers without any depression risk had 743 data points among 981 events during which there were no hospitalizations whereas patients with care providers at an increased risk of depression had 180 data points among 258 events during which there were no hospitalizations, indicating significant differences in the annual hospitalization frequencies between the two groups.

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