Raffaelle's has delighted the community for seven years
A family-run Italian restaurant in Bearsden is set to close its doors after seven years of delighting locals.
However, the owners have made the tough decision to call time on the eatery with their final day of operation taking place this Sunday, January 8.They posted on Facebook: "It’s goodbye from us at Raffaelle’s.
Australia Latest News, Australia Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Tottenham weigh up double deal to appease Conte as Italian 'continues to annoy' former clubTottenham are looking to give Antonio Conte the tools he needs for a successful season by weighing up a swoop for two Inter Milan players, according to reports...
Read more »
Family 'unanswered questions' after cabbie shot dead 28 years agoThose responsible for his death have never been brought to justice
Read more »
Waterloo Road star Adam Thomas opens up over working with real-life family members on set'It’s been an amazing experience for us all.'
Read more »
Calculating variant penetrance from family history of disease and average family size in population-scale data - Genome MedicineBackground Genetic penetrance is the probability of a phenotype when harbouring a particular pathogenic variant. Accurate penetrance estimates are important across biomedical fields including genetic counselling, disease research, and gene therapy. However, existing approaches for penetrance estimation require, for instance, large family pedigrees or availability of large databases of people affected and not affected by a disease. Methods We present a method for penetrance estimation in autosomal dominant phenotypes. It examines the distribution of a variant among people affected (cases) and unaffected (controls) by a phenotype within population-scale data and can be operated using cases only by considering family disease history. It is validated through simulation studies and candidate variant-disease case studies. Results Our method yields penetrance estimates which align with those obtained via existing approaches in the Parkinson’s disease LRRK2 gene and pulmonary arterial hypertension BMPR2 gene case studies. In the amyotrophic lateral sclerosis case studies, examining penetrance for variants in the SOD1 and C9orf72 genes, we make novel penetrance estimates which correspond closely to understanding of the disease. Conclusions The present approach broadens the spectrum of traits for which reliable penetrance estimates can be obtained. It has substantial utility for facilitating the characterisation of disease risks associated with rare variants with an autosomal dominant inheritance pattern. The yielded estimates avoid any kinship-specific effects and can circumvent ascertainment biases common when sampling rare variants among control populations.
Read more »
Benedict Cumberbatch’s family could owe Barbados as country seeks reparationsBenedict Cumberbatch’s family have reportedly been placed on a list of wealthy descendants that could be faced with a reparations fight with the Barbados government.
Read more »
Paddy& Christine McGuinness reunite for New Year's Day family outingPADDY and Christine McGuinness reunited for a New Year’s Day family outing following their split. The former couple visited Redsmere Lake, Macclesfield, to feed the ducks with their three kid…
Read more »