Nature research paper: FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation
. Although severe COVID-19 disease is linked to exuberant inflammation, how SARS-CoV-2 triggers inflammation is not understood. Monocytes and macrophages are sentinel cells that sense invasive infection to form inflammasomes that activate caspase-1 and gasdermin D , leading to inflammatory death and release of potent inflammatory mediators. Here we show that about 6% of blood monocytes in COVID-19 patients are infected with SARS-CoV-2.
Caroline Junqueira, Ângela Crespo, Shahin Ranjbar, Luna B. de Lacerda, Mercedes Lewandrowski, Jacob Ingber, Sagi Ravid, Marie Rose Schrimpf, Felicia Ho, Setu M. Vora, Hao Wu, Anne E. Goldfeld & Judy LiebermanCaroline Junqueira, Ângela Crespo, Luna B. de Lacerda, Mercedes Lewandrowski, Jacob Ingber, Sagi Ravid, Marie Rose Schrimpf, Felicia Ho, Lauren Henderson, Erin Janssen, Hao Wu & Judy LiebermanCaroline Junqueira & Luna B.
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