Scientists discuss the metabolic advantages of the ketogenic diet in the management of polycystic ovarian syndrome.
By Pooja Toshniwal PahariaAug 21 2023Reviewed by Benedette Cuffari, M.Sc. Polycystic ovary syndrome is a prevalent endocrine disorder affecting reproductive women that is driven by hyperandrogenism and insulin resistance . Treatment for PCOS often focuses on dietary and lifestyle interventions, with ketogenic diets particularly beneficial for IR and carbohydrate metabolism control.
About the study PubMed/MEDLINE, Web of Science, and Scopus databases were searched for relevant original research, clinical trials, reviews, and meta-analyses that were published within the previous 15 years in English and included human subjects. In vivo and in vitro studies, as well as studies involving older individuals and patients with malnutrition or epilepsy, were excluded from the analysis.
As a compensatory approach for excess nutrition, adipocytes produce mediators that stimulate early development and maturation in late infancy, with possible hypothalamus-pituitary axis activation and adrenarche leading to premature adolescence. The third stage, which is known as the postmenarchal phase, persists throughout adolescence and is characterized by biological development slowdown and adipocyte mediator persistence.
KD involves a decreased carbohydrate consumption of 30 to 50 grams daily, with varied protein. The fat intake ratios of this diet are aimed at inducing ketosis, during which energy is primarily obtained from ketone bodies that are produced from fat rather than glucose. The very low-calorie KD has shown considerable reductions in body mass index , fat mass, weight, and waist circumference. Weight reduction with VLCKD may be attributed to ketone bodies’ influence on hunger, which results in a lowered appetite, improved satiety, and, as a result, smaller meals and lower food intake.
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