If I Could Use Gene Therapy to Cure My Manic-Depression, I Don’t Know Whether I Would

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If I Could Use Gene Therapy to Cure My Manic-Depression, I Don’t Know Whether I Would
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Treatment saved my life, but it also felt like being ejected from paradise.

, Kay Redfield Jamison posed a question that has stayed on my mind ever since: “I have often asked myself whether, given the choice, I would choose to have manic-depressive illness.” The question haunts me because I can’t answer it, either.

.” Molecular biologists are also making progress in studies of major depression and schizophrenia. These discoveries and the explosion of gene-editing research, made possible by the gene-editing technique CRISPR, are on a path to intersect.My first onset of mania, which occurred after I left home for college, was an awakening and an addiction, akin to taking a mind-altering drug.

in their lifetime; suicide rates are 10 to 30 times higher than those of the general population. Without effective treatment, it can be a struggle to maintain loving relationships and steady employment. Without treatment, the fear of relapse is ever-present.I started taking lithium for bipolar disorder when I turned 30, and the transformation was profound. The world receded a bit; I could breathe and escape from the clamor of my own mind for the first time in a decade.

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