Genetic test can guide treatment for blood cancer to prevent relapse icrnews
isease and are approved as a single agent maintenance treatment after autologous stem cell transplantation. However patients will become resistant to ongoing therapy over time and inevitably relapse. It is only in the last decade that the mechanism of IMiD action has been elucidated; through binding to the cereblon component of the CRL4E3 ubiquitin ligase a set of neosubstrates is designated for degradation by the proteosome.
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