Symptoms include fever, headache, muscle aches, backache, swollen lymph nodes, chills and exhaustion.
The UKHSA says investigations are under way to establish links between the latest four cases, who all appear to have been infected in London.
The UKHSA says anyone with concerns that they could be infected should see a health professional, but make contact with the clinic or surgery ahead of a visit. A rash can develop, often beginning on the face, then spreading to other parts of the body. The rash changes and goes through different stages - a bit like chicken pox - before finally forming a scab, which later falls off.touching clothing, bedding or towels used by someone with the monkeypox rashRead more about the virusUKHSA chief medical adviser Dr Susan Hopkins said: "This is rare and unusual.
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