Multiple substanceusedisorders may share inherited genetic signature WUSTLmedschool NatMentHealth
the study's findings are drawn from an analysis of genomic data from more than 1.1 million people of mostly European ancestry and a smaller population of people of African ancestry.
The genetic signature associated with substance use disorders encompasses variations in multiple genes and is linked to regulation of dopamine signaling. Dopamine is a key signaling molecule in the brain's reward system. Studies have shown that repeated exposures to addictive substances can cause the dopamine pathway in the brain to adapt to the effects of these substances, requiring more of the substance in order to receive the same amount of reward.
As part of the study, the researchers compiled a list of approved and investigational pharmaceutical drugs that have the potential to be repurposed to treat substance use disorders because the drugs may target the effects of the newly discovered genetic signature associated with addiction. The list includes more than 100 drugs to investigate in future clinical trials, including those that can influence regulation of dopamine signaling.
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