Next-Generation Treatments to Help Manage Cholesterol

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Next-Generation Treatments to Help Manage Cholesterol
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Three things a cardiologist wants patients with high cholesterol to know:

By Stephen L. Kopecky, MD, as told to Susan Bernstein

PCSK9 drugs, which are monoclonal antibodies, are another game-changer in cholesterol management. These drugs block the PCSK9 protein. As low-density lipoprotein cholesterol -- what people call “bad” cholesterol -- goes into your liver, the PCSK9 will hold the LDL and the LDL receptor together. PCSK9 inhibitors have the same side effect profile as statins, including myalgias and nasal stuffiness, although this usually goes away. These drugs have also started to come down in price, and more insurance companies are accepting them. This treatment is very helpful for patients with familial hypercholesterolemia who may not be able to get to their cholesterol goals with a combination of a statin and ezetimibe alone. The PCSK9 drug works on top of the statin and ezetimibe for these patients.

PCSK9 drugs were game-changers. For the first time in the history of our species, people with familial hypercholesterolemia have a treatment option. Lipoprotein-a drugs will be a game-changer too.

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