As surprise pregnancies multiply, some scientists are investigating whether weight loss drugs can improve fertility in women with polycystic ovary syndrome
athryn started taking Ozempic “off label” in April 2023 on her doctor’s advice. The Illinois resident had been diagnosed with gestational diabetes while pregnant and was struggling with her weight after the birth of her daughter. Following a short break from the drug in July because of side-effects, she started taking it again in August. In September, she found out she was pregnant.
But there’s also another theory that posits that drugs such as Ozempic may interfere with the efficacy of birth control pills. These new diabetes and weight loss medicines mimic a natural gut hormone called GLP-1 that has three main functions – boosting insulin, slowing the emptying of the stomach and acting on parts of the brain that regulate hunger. It’s the second function that could hamper the body’s absorption of oral contraceptives, leading to surprise pregnancies.
“The whole contraceptive pill issue is still a little uncertain in terms of the extent to which it’s influencing these pregnancies,” Balen says. The absorption factor could have some bearing but weight loss is likely to be the bigger reason, he adds. There could also be another mechanism at play, according to Cree. In pilot MRI studies, her team noticed changes in brain connectivity in women with PCOS taking semaglutide. “The part of the brain that senses calories, the hypothalamus, was better connected to the parts of the brain that do decision making,” she tells me.
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