Reduced butyrate production in the microbiome of type 2 diabetics Diabetes Microbiome Type2Diabetes Butyrate TH_Wildau goetheuni
By Dr. Priyom Bose, Ph.D.Feb 15 2023Reviewed by Benedette Cuffari, M.Sc. In a 2020 World Health Organization report, diabetes mellitus was featured as one of the top 10 leading causes of death. Diabetes is a metabolic disease that has certain hereditary predispositions. Early detection of this disease can be aided by developing a deeper understanding of the association between diabetes, particularly type 2 diabetes , and the gut microbiome.
The intestine is often referred to as the control center of the body, as it plays a crucial role in both digestion and supporting the immune system. The intestinal microbiota is a complex composite of bacteria, fungi, and viruses, with bacteria accounting for the largest share. The microbiome composition varies with factors, such as lifestyle, environment, age, and gender.
About the study The data for this study was provided by BIOMES NGS GmbH, which included information on the microbiome and individual lifestyle characteristics such as height, weight, age, and diet, to name a few. The diversity of the gut microbiome in T2D patients was lower than in the control group, which is consistent with previous studies. Blautia, Bacteroides, Lachnoclostridium, and Prevotella had an increased presence in the T2D group as compared to the control group. The opposite was observed with regard to other significant genera.
The T2D group exhibited a significant reduction in Alistipes, Anaerostipes, and Ruminococcus. Conversely, healthy controls exhibited high levels of Ruminococcus and Anaerostipes. Roseburia, Lachnospira, Faecalibacterium, and Coprococcus, which are producers of butyrate, were similarly reduced in the T2D group.
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