Microscope based on fiberoptic components designed for studying cellular effects of drug combinations. Researchers have developed a fluorescence microscope that uses structured illumination for fast super-resolution imaging over a wide field of view. This advanced microscope is tailored to capture
Researchers developed a fluorescence microscope that uses structured illumination for fast super-resolution imaging over a wide field of view. It can also be used for multicolor and high-speed imaging. Credit: Henning Ortkrass, Bielefeld University
“Polypharmacy — the effect of the many combinations of drugs typically prescribed to the chronically sick or elderly — can lead to dangerous interactions and is becoming a major issue,” said Henning Ortkrass from Bielefeld University in Germany. “We developed this microscope as part of the EIC Pathfinder OpenProject DeLIVERy, which aims to develop a platform that can investigate polypharmacy in individual patients.
The new fluorescence microscope uses structured illumination for fast super-resolution imaging over a wide field of view. Multicolor imaging can also be performed, as shown in the video. Credit: Henning Ortkrass, Bielefeld UniversityThe new microscope is based on super-resolved structured illumination microscopy , which uses a structured pattern of light to excite fluorescence in a sample and achieve a spatial resolution beyond the diffraction limit of light.
“The fiber selection and phase shift is performed using a newly designed fiber switch based on galvanometric mirrors and MEMS-mirrors,” said Ortkrass. “We also custom-designed a hexagonal holder that collimates and refocuses the beams of the six fibers into the microscope to illuminate a large FOV and allow precise adjustment of all beams.
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